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Which of the following is the best approach to confirm the diagnosis of an acute cytomegalovirus infection (CMV)?
A.
Clinically with fever and rash
B.
Isolation of the virus from urine
C.
Isolation of virus from saliva
D.
Isolation of the virus from blood
E.
Isolation of virus from stool
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C)
...im guessin saliva coz
*ELISAs for CMV antigen in the urine carry low sensitivity as CMV is complexed to ß2-microglobulin in the urine.
*blood can b false +ve d/t transfer in bld transfusion
*stool not done
.....so..
...........wht hav u 2 say ?
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The answer is: D
Isolation of virus from blood or demonstration of a fourfold or greater rise in antibody is the most reliable means of diagnosis of an acute infection of CMV. Excretion of CMV in the urine or the saliva can persist for months. Clinical findings alone are insufficient to differentiate CMV infection from other acute virus infections.
