09-03-2009, 08:45 PM
Which one is right, Increased or decreased digoxin effect ?
1) Spironolactone....> possible hyperK.....>decrease digoxin effect.
2) Spironolactone....>inhibit tubular secretion of digoxin causing INCREASE in its effect (toxicity)
1) Spironolactone....> possible hyperK.....>decrease digoxin effect.
2) Spironolactone....>inhibit tubular secretion of digoxin causing INCREASE in its effect (toxicity)