findings are most consistent with a diagnosis of? - faster

[ArchivalUser]

53-year-old male presents with an enlarged supraclavicular
lymph node, and physical examination reveals enlargement
of the Waldeyer ring of orophatyngeal lymphoid
tissue. There is no hepatosplenomegaly. Lymph node biopsy
reveals replacement by a monomorphous population
of large lymphoid cells with enlarged nuclei and prominent
nucleoli. The CBC is normal except for findings of mild
anemia. Immunohistocliernical staining and flow cytonietry
of the node reveals that most lymphoid cells are CD19 + ,
CD10+, CD3- , CD15 -, and terminal deoxynucleotidyl
transferase negative(TDT-). These clinical, histologic, and
phenotypic findings are most consistent with a diagnosis of
(A) Chronic lymphadenitis
(B) Diffuse large B-cell lymphoma
© Hodgkin disease
(D) Lymplioblastic lymphoma
(E) Small lymphocytic lymphoma

[ArchivalUser]

bbb

[ArchivalUser]

bbb

[ArchivalUser]

i think b

[ArchivalUser]

THE CORRECT ANSWER IS BB

[ArchivalUser]

could you please post the explaination faster?

[ArchivalUser]

B) Diffuse large B-cell lymphoma occurs in older individuals
and frequently presents as localized disease with
extranodal involvement, particularly of the Waldeyer ring.
The staining pattern indicates a B-cell proliferation
(CD19+, CD10). T-cell (CD3) and monocytic (CD15)
markers are absent. TdT can be expressed in B-lineage
cells at an earlier stage of maturation. Small lymphocytic
lymphoma is also a B-cell neoplasm, but it manifests with
widespread lymphadenopathy, liver and spleen enlargement,
and lymphocytosis. Lymphoblastic lymphoma is a T cell neoplasm that occurs typically in the mediastinum of
children. Hodgkin disease is characterized by Reed-Sternberg
cells. In chronic lymphadenitis, the lymph node has
many cell types”macrophages, lymphocytes, and plasma
cells. A monomorphous infiltrate is typical of non-Hodgkin
lymphomas.