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Which of the following is an example of a glycosylated integral membrane protein with 7
transmembrane segments?
A. Adenylate cyclase
B. Beta-adrenergic receptor for epinephrine
C. Cystic fibrosis transmembrane conductance regulator channel
D. Glucose transporter
E. Na+/K+ ATPase
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answer is B.
This question requires that you recognize the family of receptors that
interact with G proteins to initiate a signal transduction cascade. These receptors are all
glycosylated integral membrane proteins that have 7 transmembrane segments. Beta-adrenergic
receptors for epinephrine are an example.
Adenylate cyclase (choice A) is an intracellular effector protein involved in signal
transduction. It is not an integral membrane protein.
The cystic fibrosis transmembrane conductance regulator channel (choice C) is a cyclic AMP
activated chloride channel.
Glucose transporters (choice D) are integral membrane proteins with 12 membrane-spanning
domains.
Na+/K+ ATPase (choice E) pumps sodium into and potassium out of the cell. It provides energy
for active transport by hydrolyzing ATP.
