05-12-2010, 04:16 PM
43. A 32-year-old man with hypertension comes to the physician for a follow-up examination. He has been treated with a beta-adrenergic blocking agent for the past 6 weeks. His blood pressure now is 145/90 mm Hg. Physical examination shows no abnormalities. Hydrochlorothiazide is added to the medication regimen. Which of the following best describes the renal mechanism of action of hydrochlorothiazide in this patient?
A. Blocks the mineralocorticoid receptor in the late distal tubule and collecting duct
B. Blocks the Na+-K+-2Cl- symporter
C. Blocks the sodium channel in the late distal tubule and collecting duct
D. Inhibits the Na+-Cl- symporter
E. Produces osmotic diuresis
F. Stimulates carbonic anhydrase in the proximal tubule
A. Blocks the mineralocorticoid receptor in the late distal tubule and collecting duct
B. Blocks the Na+-K+-2Cl- symporter
C. Blocks the sodium channel in the late distal tubule and collecting duct
D. Inhibits the Na+-Cl- symporter
E. Produces osmotic diuresis
F. Stimulates carbonic anhydrase in the proximal tubule