05-29-2010, 06:29 PM
a 50 year old man with type 2 DM & hypertension comes to the physician because of puffiness of his face & hands, fatigue, & a 5 kg (11 lb) weight gain during the past week. He had a sore throat & coryza 2 weeks ago that resolved after 2 days. He is 175cm (5 ft 9in) tall & now weighs 123 kg (270lb); BMI is 40kg/m2. His temperature 37.2C (99F), pulse is 90/min, resp are 20/min, & bp is 160/100mmHg. Physical examination shows generalized edema, most marked in the periorbital areas, & pitting edema of the lower extremities. Lab studies show an increased serum total cholesterol concentration, proteinuria, & no hematuria or casts. A photomicrograph of a renal biopsy specimen is shown. Which of the following is the most likely diagnosis?
a) Diabetic glomerulosclerosis
b) Membranous glomerulonephritis
c) Minimal change disease
d) Poststrep glomerulonephritis
e) Rapidly progressive glomerulonephritis
a) Diabetic glomerulosclerosis
b) Membranous glomerulonephritis
c) Minimal change disease
d) Poststrep glomerulonephritis
e) Rapidly progressive glomerulonephritis