Renal Immuno Q - usmedipro

[ArchivalUser]

A 2-year-old child with leukemia develops nephrotic syndrome.
Light microscopic studies are normal. Electron microscopic studies
demonstrate fusion of epithelial foot processes. The current hypothesis
for the pathogenesis of this change is that it is secondary to which
of the following?
A. Consumption of complement factors
B. IgG directed against basement membrane
C. Immune complex deposition
D. Lymphokine production by T cells
E. Mesangial IgA deposition

[ArchivalUser]

ccc..imune complex deposition

[ArchivalUser]

E. Mesangial IgA deposition

[ArchivalUser]

DD

[ArchivalUser]

if light microscopic findings are normal and electron microscope findings are epithelial foot process fusion- in a child- the most commmon cause of NS is ??
Now think of the answer...

Immune complex deposition- will be found in postinfectious GN, lupus nephropathy,bacterial endocarditis, cryoglobulinemia, henoch schonlein pupura.

Mesangial IgA nephropathy is Bergers disease-IgA nephropathy often found in young adults after a URI and causes a nephritic picture and not nephrotic syndrome.

(These 2 are not a common cause of NS but they cause Glomerulonephritis.)

[ArchivalUser]

Its minimal change disease. Its often postinfectious, so I would guess that there would have been T cells involved before. So D

[ArchivalUser]

Yes its D... I am always confused and forget that minimal change disease is postinfectious.

[ArchivalUser]

there...you got it now.