07-01-2010, 08:14 PM
* The enzyme converts HMG CoA to mevalonic acid, a cholesterol precursor.
* Statins inhibit HMGR --- decrease intrahepatic cholesterol --- upregulation of hepatic LDL cholesterol receptors ----lowering plasma LDL cholesterol levels.
* Statins inhibit HMGR --- decrease intrahepatic cholesterol --- upregulation of hepatic LDL cholesterol receptors ----lowering plasma LDL cholesterol levels.