nbme7 blk2 q28 - lady

[ArchivalUser]

52y/o woman with ductal cell carcinoma with metastase to lung and liver died. her mother and sister were died of breast cancer. which of the molecullar abnormality is the reason?

a.amplification of HER2 gene in somatic cell
b.amplification of N-MYC in neoplastic cell
c.deletion of rb in healthy somatic cell
d. germline inactivation of BRCA1 gene

[ArchivalUser]

DDDDDDDDDDDDDDDDDDDDDDDDD. Right

[ArchivalUser]

can you explain it ,why a is not right?! HER2 could cause breast cancer too!?

[ArchivalUser]

the mutation which runs in families is a germline not ( somatic ) , the later usually is secondary to external stimuli.

[ArchivalUser]

you are 100% right, thank you

[ArchivalUser]

lady i need to ask you some Q if u do't mind regarding nbme??????