please help with sjogren's syndrome &antibodie - momydoc

[ArchivalUser]

please some one clear my doubt which one (anti-Ro/ssa &anti-la/ssb) is more specific ?in mtb page 128 both are fairly specific &kaplan qbank >>anti-la/ssb is more specific.
thanks in advance.

[ArchivalUser]

important thing to remember is- do not always think- anti Ro is for Sjogren only- it is used in diagnosis of lupus with ANA negative patients and with negative antiphospholipid AB but prenatal care is important in pregnant patients cause foetus can have heart block in these patients.

[ArchivalUser]

thanks diuretics for your info ,but as i got 2qs i assumed its important point to clear.thanx again.

[ArchivalUser]

anti-Ro (SSA), antibodies are more specific to sSs patients than anti-La (SSB) . Sjogren`s syndrome

[ArchivalUser]

Measurements of Autoimmunity
When certain autoantibodies are present, this provides valuable diagnostic information for SLE. . The most common and specific tests for autoantibodies and other elements of the immune system are listed first.

Antinuclear Antibody (ANA)
A screening test for ANA is standard in assessing SLE because it is positive in close to 100 percent of patients with active SLE. However, it is also positive in 95 percent of patients with mixed connective tissue disease, in more than 90 percent of patients with systemic sclerosis, in 70 percent of patients with primary Sjögren’s syndrome, in 40 to 50 percent of patients with rheumatoid arthritis, and in 5 to 10 percent of patients with no systemic rheumatic disease. Patients with SLE tend to have high titers of ANA. False-positive results are found during the course of chronic infectious diseases, such as subacute bacterial endocarditis, tuberculosis, hepatitis, and malaria. The sensitivity and specificity of ANA determinations depend on the technique used.

Anti-Sm
Anti-Sm is an immunoglobulin specific against Sm, a ribonucleoprotein found in the cell nucleus. This test is highly specific for SLE; it is rarely found in patients with other rheumatic diseases. However, only 30 percent of patients with SLE have a positive anti-Sm test.

Anti-dsDNA
Anti-dsDNA is an immunoglobulin specific against native (double-stranded) DNA. This test is highly specific for SLE; it is not found in patients with other rheumatic diseases. Fifty percent of patients with active SLE have a positive anti-dsDNA test. For many patients with anti-dsDNA, the titer is a useful measure of disease activity. The presence of antidsDNA is associated with a greater risk of lupus nephritis.

Anti-Ro(SSA) and Anti-La(SSB)
These immunoglobulins, commonly found together, are specific against RNA proteins. Anti-Ro is found in 30 percent of SLE patients and 70 percent of patients with primary Sjögren’s syndrome. Anti-La is found in 15 percent of people with lupus and 60 percent of patients with primary Sjögren’s syndrome. Anti-Ro is highly associated with photosensitivity; both are associated with neonatal lupus.

[ArchivalUser]

pk

[ArchivalUser]

thanx alot spatans1.