12-01-2010, 05:08 PM
A 26-year-old woman presents with 2 weeks of nausea,
vomiting, and jaundice. She has been previously
healthy and has no past medical history. On examination,
a palpable liver edge is appreciated. Ocular findings are
presented in Figure X-14 (Color Atlas). Her transaminases
and total bilirubin are elevated. Which of the following
tests will lead to a definitive diagnosis in this patient?
A. Anti-smooth-muscle antibody
B. Hepatitis B surface antigen
C. Liver biopsy with quantitative copper assay
D. Serum ceruloplasmin
E. Total iron-binding capacity and ferritin
vomiting, and jaundice. She has been previously
healthy and has no past medical history. On examination,
a palpable liver edge is appreciated. Ocular findings are
presented in Figure X-14 (Color Atlas). Her transaminases
and total bilirubin are elevated. Which of the following
tests will lead to a definitive diagnosis in this patient?
A. Anti-smooth-muscle antibody
B. Hepatitis B surface antigen
C. Liver biopsy with quantitative copper assay
D. Serum ceruloplasmin
E. Total iron-binding capacity and ferritin