09-26-2005, 07:14 AM
Mechanism please?
How does Heparin cause osteoporosis? - nini
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09-26-2005, 07:14 AM
Mechanism please?
09-27-2005, 06:08 AM
Heparin is found to enhance both IL-11-induced STAT3-DNA complex formation and transactivation without altering either STAT3 (signal transducer and activator of transcription-3) tyrosine or serine phosphorylation. Heparin was also found to enhance IL-11's ability to induce the expression of both receptor activator of nuclear factor-B ligand (RANKL) and glycoprotein (gp) 130. When taken together, these findings suggest a plausible mechanism by which heparin may cause increased osteoclastogenesis and therefore bone loss when administered long-term.
Hope this helps...found it on a website.....good luck |
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