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NBME#1 block 2 Q1-----------Q50 - maryam2009
#11
@ anonyme
All the numbers are given for a 2 year period;so, how do we know that was an equal number of cases in each of those 2 years?
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#12
hmm.. gud point..

shall we continue to q11-20....
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#13
Q3.A

Cocaine binds to dopamine re-uptake transporters on the pre-synaptic membranes of dopaminergic neurones. This binding inhibits the removal of dopamine from the synaptic cleft and its subsequent degradation by monoamine oxidase in the nerve terminal. Dopamine remains in the synaptic cleft and is free to bind to its receptors on the post synaptic membrane, producing further nerve impulses. This increased activation of the dopaminergic reward pathway leads to the feelings of euphoria and the ‘high’ associated with cocaine use.

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#14
Q4. C
Recombination- exchange of genetic material
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#15
Q5. C

Sulfonylureas-->Closing of the K channels --->depolarization-->release of insulin via Calcium influx--> hypoglycemia
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#16
Q5.c
close K+ in beta cell memberane.....cell depolarizes.....triggering of Insulin release via inc. Ca+ influx
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#17
Q7. F

Insulin, IGF-1, FGF, PDGF -act through receptors which contain tyrosine kinase
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#18
Q6.?
A or B the answer was B
collision................in 2 year.........600,000 population
800 (600 alcoholic+200 non alc.)
400 dead of collision(300 alc.+100 non alc)
representation of 1 -year incidence of alcohol related fetalities in this community?

if 300 per 600,000 in 2 years,why not 150 per 600,000 in 1 year?
please explain
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#19

amusmle - 03/07/11 17:04

For Q6 It could be either A or E. I'm thinking we can not exactly determine the number of fatalities from the information given. What do you think? A or E?



anonyme - 03/07/11 17:21

@ amusmle.. @ Q6... why do u think it is E....?? marya, have any idea...??



amusmle - 03/07/11 17:30

@ anonyme
All the numbers are given for a 2 year period;so, how do we know that was an equal number of cases in each of those 2 years?
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#20
may be the Q is about the cause -specific mortality rate=Deaths from cause/population
if it is then the choice B is the answer
Is there any new idea or explanation? Thank you
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