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9=FF
types of enzyme linked receptars -
A-Receptar tyrosine kinases:
1-epidermal growth factor receptar
2-platelet derived growth factor receptar
3-fibrobalst growth factor receptar
4-nerve growth factor receptar
5-vascular endothelial growth factor receptar
6-insulin receptar
B-Tyrosine kinase - associated recepatrs
1-cytokine receptar
2-growth harmone recepatr
3-prolactine harmone recepar
4-Antigen specific recepatr on B and T lymphocytes
5-IL 2 receptar
c-recepatar tyrosine phosphatase-
CD45
D-Recepatr serine threonine kinase
transforming growth factor Beta recepatar
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9.C
The JAK-STAT signaling pathway transmits information from chemical signals outside the cell, through the cell membrane, and into gene promoters on the DNA in the cell nucleus, which causes DNA transcription and activity in the cell. The JAK-STAT system is a major signaling alternative to the second messenger system. The JAK-STAT system consists of three main components: a receptor, JAK and STAT.
JAK is short for Janus Kinase, and STAT is short for Signal Transducer and Activator of Transcription.
The receptor is activated by a signal from interferon, interleukin, growth factors, or other chemical messengers.
This activates the kinase function of JAK, which autophosphorylates itself (phosphate groups act as "on" and "off" switches on proteins). The STAT protein then binds to the phosphorylated receptor. STAT is phosphorylated and translocates into the cell nucleus, where it binds to DNA and promotes transcription of genes responsive to STAT.
JAKs, which have tyrosine kinase activity, bind to some cell surface cytokine receptors. The binding of the ligand to the receptor triggers activation of JAKs.
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u r cool drona ...thnx a lot
thnx to u too maryam
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correction................................Q9.FFFFFFFFFF
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10.A
Acetaminophen toxicity causes hepatic necrosis,,,,,,,its methabolite depletes glutathione
N-acetylcystein is antidoe.....>regenerates glutathion
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11.B
protease inhibitors inhibit maturation of new virus by blocking protease in progeny virions.
SAQUINAVIR,RITONAVIR,INDINAVIR..........-NAVIR
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q12? 13,answer is C,poliovirus is a icosahedral,positive sense,ssrna ,causes FUO,aseptic meningitis,flaccid paralysis,no sensory loss,sabins vaccine or salks killed vaccine is given
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q14,E,mycoplasma,viruses ricketssiae all are very small in size less than 0.45micron,here only staph aureus can be removed,becoz it is greater than given size,if it were only 0.22micron filter only viruses would pass,if the diameter of a cell described in a clinical case is greater than 2 micron it would be a eukaryotic cell
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q15--DD
we are looking for male mouse
(A X B) XF1 male where A from father and B shud be from mother only D option shows it.
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