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75 year old male professional golfer presents to his physician with a lesion on the lateral aspect of his nose that has been present for several months. When questioned about sun exposure he states during his playing career he rarely wore a hat or sunscreen. On exam, the lesion is papular with rolled edges and appears pearly. This lesion most likely arose from which of the following?
A. stratum corneum
B. melanocytes
C. stratum granulosum
D. stratum spinosum
E. stratum basale
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A basal cell carcinoma is a skin cancer that originates from basal keratinocytes in the top layer of the skin, the epidermis
Basal keratinocytes are unpigmented skin cells found deep in the epidermis, hair follicles, and sweat glands
. When they become cancerous, these cells invade the dermis (the layer of skin just below the epidermis) and spread out into the normal skin.
They become visible as a small growth or area of change in the skin's appearance. These tumors can appear anywhere on the body, but most become evident on the face and neck.
