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exam in july/aug - doc_aim
#81
For =Perfusion limited ---
D= solubility---CO2 is more soluble than O2, so cross alveolar membrane quicker than O2.
P1- P2---PAo2- PaO2=100-40=60mmhg when blood FIRST enter pulmonary capillary. This gradient is drive for simple diffusion and gas equiliberate early along the lenth of the capillary.It is not diffusion limited per definition above.
For CO2, P1- P2---PACO2- PaCO2=47-40=7mmhg .Gradient is less than O2, but diffuse faster and equilibrate earlier than O2 even because D (solubility is higher than O2).
So because diffusion is not limited .So normal is perfusion limited.
Diseased lung is diffusion limited.
In diseased lung if u give pt supplemental oxygen, PAO2 increased, so gradient across membrane increased. PO2 will return to normal .Vgas (rate of gas diffusion)increase if P1- P2 increase.
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#82
medico25- it is from FA and Kaplan 2010 LN pg 165.I found it helpful for me to understand that topic.
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#83
thats reallly nice of u .....very welll explained !!!
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#84
Why does arginine increase insulin promotion?..
THey mention only arginine amongst all amino acids ...y ?
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#85
I mean promote insulin synthesis
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#86
@medico25 yup i needed to knw tht too!!!
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#87
hi,
pls join me in tooo. planning to give exam in september. jst started wid uworld. i did d kaplan notes all d subjects n golgan audio. pls let me knw if i also need to watch kaplan videos for some subjects?



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#88
draz ......did u notice ..in insulin they say --- Arginine and glucagon or sumthng they bring up Arginine and leucine....why why ?
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#89
am sorry not glucagon ....arginine and leucuine promotes the GH secretion...
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#90
@ medico25

Here is an interesting article about how arginine and leucine stimulate insulin secretion.

http://diabetes.diabetesjournals.org/con...2/S39.full



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