can anyone plz explain? - sanak

[ArchivalUser]

how does mannitol cause pul edema if its indication is to reduce intracranial pressure..?plz explain ...thanks in advace

[ArchivalUser]

I hope this exlanation helps youl

from BRS physio 4th ed: mannitol is a marker for ECF because it is a large molecule that cannot cross CM and is therefore excluded from the ICF.

Circulatory overload due to expansion of extracellular fluid is a serious adverse effect of mannitol, as a consequence, pulmonary edema can be precipitated in patient with diminished cardiac reserve, and acute water intoxication may occur in patient with inadequate urine flow. Interstitial edema is determined by starling forces,, so its possible that the increased hydrostatic pressure created by the mannitol offsets the increased oncotic pressure leading to extravasation of fluid.

posted by LaBi22939381