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How does prostaglandin block adh - step1saga

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How does prostaglandin block adh - step1saga
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#1
07-05-2011, 06:44 PM
Indomethacin blocks prostaglandins which blocks adh so it can be used in diabetes insipidis but how does pg do that?
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#2
07-06-2011, 12:00 AM
Why would u block ADH if patients w/ DI have low ADH to begin with? Maybe indomethacin uses a different mechanism in treating DI. I know indomethacin will decr GFR by vasocontricting the afferent arterioles... maybe thats how u decrease the urine production in patients w/ DI. But Im not quite sure.
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