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A 28-year-old woman, who is in the 12th week of her pregnancy, presents to the emergency room with vaginal bleeding. P/E showed that her uterus is large for gestational age. V/E reveals a grape-like mass protruding form the cervical os. Microscopic examination of the mass revealed large, edematous cells with a large central cavity, surrounded by a proliferation of cytotrophoblasts and syncytiotrophoblast.
Chromosomal analysis of the tissue would most likely show which of the following karyotypes?
A. 45XO
B. 46XX
C. 47XXY
D. 55XY
E. 69XXY
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bbbbb molar chromosomes are derived from father , haploid sperm duplicates its own chromosomes
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a partial mole occurs when an egg is fertilized by two sperm or by one sperm which reduplicates itself yielding the genotypes of 69,XXY (triploid) or 92,XXXY (quadraploid).
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EEE is partial mole, right?
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what about this, do we get 69xxx? and why?
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@saad_usmle
Partial mole is for scound Q...
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As katy said, in partial mole, the haploid egg is fertilized by either one diploid or two haploid sperm resulting in triploid karyotype, i.e. 69XXY.
@saad_usmle, answer E is partial mole.
