10-10-2011, 04:20 PM
can anybody explain these effects and where protons r more tissue or lung?
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bohr and halden effect - naveerah
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10-10-2011, 07:12 PM
Its all abt 3 components H+,o2,co2 movements onto &off the Hb.
Allosteric i.e shape change in Hb molecule is responsible 4 o2 loading and unloading at lungs and tissues. These reactions ae called HALI HETEROTROPIC ALLOSTERIC LIGAND INTERACTION i.e 80% bohr effect and 20 % haldane effect.
10-10-2011, 07:15 PM
Haldane effect
deoxygenated Hb has higher affinity for co2 than oxygenated Hb. .'. O2 delievery at tissues promotes CO2 uptake by deoxygenated Hb & vice versa. Exchange of oxygen and carbondioxide occurs at same time i.e O2 loading and unloading assist cO2 unloading and loading at lungs and tissues respectively.
10-10-2011, 07:19 PM
Bohr effect
Its significance is appreciated more on fetus Hb. Deoxygenated Hb has more affinity for H+ than oxygenated Hb. .'. O2 release at tissues facilitates H+ picking and O2 pickup at lungs facilitates H+ release. Exchange of O2 and H+ occur at same time i.e O2 loading and unloading is assosiated with H+ unloading and loading at lungs and tissues respectively.
10-10-2011, 07:34 PM
Bohr effect: in tissue: Hb unloads O2 and takes H+ and Co2. That shifts the equation to the right; so HCO3 leaves and Cl- gets in (chloride shift).
Haldane effect: in the lung: Hb dissociates H+ so more hydrogene ions on the right which leads to shift the equation to the left, so more CO2 leaves the RBC and more HCO3 gets in and more Cl- gets out (reversed Cl- shift). |
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