MI............q? - jamebond

[ArchivalUser]

A histological section of the left ventricle of a deceased 28-year-old white male shows classic
contraction band necrosis of the myocardium. Biological specimens confirm the presence of cocaine and metabolites. Activity of which of the following enzymes was most likely increased in the patient's myocardial cells shortly prior to his death?

A. Phosphoenolpyruvate carboxykinase
B. Phosphofructokinase-1
C. Pyruvate dehydrogenase
D. Isocitrate dehydrogenase
E. Transketolase
F. Fructose 1-6 bisphosphatase
G. HMG-CoA synthase

[ArchivalUser]

B I think

[ArchivalUser]

bbb

[ArchivalUser]

Low ATP ---> + PFK-1

[ArchivalUser]

BBB Rate limiting enzime on anaerobismo. On heart attack ATp decrease and AMP will increase, this ratio will estimulate the PFK1

[ArchivalUser]

BB

Cocaine causes contraction band necrosis by blocking the reuptake of norepinephrine, resulting in excessive vasoconstriction of coronary vessels, leading to ischemia and infarction of heart tissue. Under these pathological conditions, myocardial cells switch to anaerobic metabolism and therefore glycolysis becomes the sole source of ATP via substrate-level phosphorylations by phosphoglycerate kinase and pyruvate kinase. Phosphofructokinase-1 (PFK-1) is the rate-limiting enzyme of glycolysis, and its activity would therefore be increased.