immuno question - usmleart

[ArchivalUser]

Blood sample from a 22 yr old male with infection shows leukocytosis. Differential Leukocyte count shows 58% neutrophils, 39% lymphocytes, 2% eosinophils, 0% basophils. Peripheral smear shows red cells with intracellular bodies. A test is done where leukocytes are exposed to Nitroblue tetrazolium but the cells remain colorless. What could be the most likely cause of this patients presentation?

A. Chronic granulomatous disease
B. G6PD deficiency
C. Myeloperoxidase deficiency
D. Chediek higashi syndrome
E. Malaria

[ArchivalUser]

aa

[ArchivalUser]

is it G6PD Deficiency?

[ArchivalUser]

AA

[ArchivalUser]

A..

[ArchivalUser]

classic screening test for CGD is NBT test

- A

[ArchivalUser]

I go with BBB!

[ArchivalUser]

AAA

[ArchivalUser]

tricky q i d pick " BB""

1. G6PD deficiency -----------> no NADPH-----------> no superoxide free radicals.(colorless neutrophils)

2. + Heingz bodies in RBCs

SO, PATIENTS with G6PD deficiency also may have recurrent infections with Catalase + Bugs, as in CGD.

Thank You for the nice Q))

[ArchivalUser]

thankyou all for trying

Answer is B....G6PD deficiency