Question......... - psychmledr

[ArchivalUser]

In a patient with severe retrosternal chest pain, nitroglycerin infusion results in pain relief and a decrease in blood pressure. Which of the following is the most likely intracellular consequence of nitrate administration in target tissues?

A. Actin phosphorylation
B. Tyrosine kinase activation
C. Myosin dephosphorylation
D. Cyclic mononucleotide degradation

[ArchivalUser]

CC myosin dephosphorylation..?

[ArchivalUser]

Cc

[ArchivalUser]

C....myosin dephosphorylation

some general concepts

1. Gs = net intracellular effect is phosphorylation
2 Gq = net intracellular result is phosphorylation
3. cGMP = net result is dephosphorylation
4. Tyrosine kinase = net result is dephosphorylation

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[ArchivalUser]

cc

[ArchivalUser]

Answer is C

Nitrate drugs mimic the action of endothelial derived relaxing factor (nitric oxide, NO). They are transformed to NO at the vascular smooth muscle cell membrane which leads to increased cGMP, decreased intracellular calcium and myosin dephosphorylation.