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nice NBME Q - drguirand
#1
An 82-year-old woman is brought to the physician by her granddaughter because of a 6-week
history of increasing forgetfulness. She is a retired schoolteacher and lives independently. Her granddaughter is concerned because on several occasions she has left the stove on when she went to bed. During conversations with her granddaughter, she has difficulty remembering past events and seems unconcerned about her memory lapses. The patient describes trouble sleeping through the night and has had a decreased appetite resulting in a 4.5-kg (10-lb) weight loss over the past month. She has a history of similar symptoms 2 and 5 years ago that were successfully treated with medication. She appears unkempt and has poor personal hygiene. Her temperature is 37 C (98.6 F), blood pressure is 110/70 mm Hg, and pulse is 80/min and regular. Mental status examination shows psychomotor retardation, a flat affect, impaired ability to recall past events, and trouble repeating three numbers in sequence. She is unable to recall the names of recent presidents. Her serum urea nitrogen (BUN) level is 25 mg/dL, and serum creatinine level is 1.7 mg/dL.

For each patient with cognitive impairment, select the most likely diagnosis.
A ) Acute stress disorder
B ) Dementia, Alzheimer's type
C ) Dissociative amnesia
D ) General paresis
E ) Head trauma
F ) Hepatolenticular degeneration (Wilson's disease)
G ) HIV encephalitis
H ) Huntington's disease
I ) Major depressive disorder
J ) Multi-infarct (vascular) dementia
K ) Niacin deficiency
L ) Normal-pressure hydrocephalus
M ) Parkinson's disease
N ) Pick's disease
O ) Schizophrenia, catatonic type
P ) Normal aging


Please give explanation...enjoy!
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#2
psych qs are the most challenging ones.

Alzheimer
memory loss
lack of insight
executive function impaired (unkept, poor hygiene)
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#3
actually poor hygiene may be a sign of apraxia too. In any case she lost her ability to live independently.
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#4
Important clues are:

1.) that this new forgetfulness happened rapidly over course of 6 weeks.

2.) Similar occurrence was medically treated in the past 2 and 5 years ago...

3.) Renal failure.

R/O Picks - no mention of personality changes.

DDx:

Alzheimers

Multi infarct Dementia

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#5
Anyone??
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#6
why i don't think it is vascular

1. no organic neuro signs

2. normal BP

3. vascular has a step wise deterioration
regarding history of past events that were successfully treated: if you loo at the text again, it says it comes after trouble sleeping and loosing weight, she might have some other condition leading to impaired sleep and weight loss, which were treated.

4. lastly the q says: 6 weeks of INCREASING forgetfulness. it means that the memory problems were there earlier, but now they increased to the point that the family is concerned.
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#7
I....PSEUDODEMENTIA
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#8
in pseudodementia there is insight into the memory impairment. Patients with pseudodementia generally come to the doctor by themselves, whereas pts with real dementia are normally brought in by a family member.
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#9
The forgetfulness is the predominant symptom here... and the Age fits well with Alzheimers, I like B, but the psychomotor and flat affect is throwing me off.
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#10
as disease progresses alzheimer pts develop psychotic symptoms including emotional withdrawal and delusions like somebody going to poison them, stealing their money and etc.
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