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Hyponatremia -
#1
bill - bilallll

39) A 43-year-old woman is admitted for new-onset of seizures in the setting of hyponatremia. At baseline, she is well educated and works as a computer marketer. Her medical history is remarkable for a long history of depression and alcoholism, with multiple visits to the Emergency Department for trauma. She was initially found in her hot apartment by paramedics. At that time, she was postictal, incontinent of urine, and oriented only to name. She was last seen at work 3 days ago. In the Emergency Department her systolic blood pressure is 70 mm Hg and her pulse is 130/min. Upon physical examination, she has dry mucous membranes, a jugular venous pressure of less than 5 cm, and diffuse ecchymoses on her face, body, and breasts. She proceeds to have two addition seizures in the Emergency Department that are controlled with intravenous lorazepam. Laboratory studies reveal a serum sodium of 115 mEq/L, potassium of 2.8 mEq/L, and bicarbonate of 32 mEq/L. Which of the following is the most appropriate next test to obtain?

A. Electroencephalogram (EEG)
B. Magnetic resonance imaging (MRI) of the head
C. Non-contrast computed tomography (CT) of the head
D. X-ray films of the skull
E. Lumbar puncture (LP)

Can anyone discuss this question shedding lights as to why any particular answer is chosen?
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#2
skynerve

CT Head - to exclude reversible causes - intracranial hematoma as a result of trauma, SAH etc. etc, which you have a clue here from the diffuse ecchymoses. (odds are that she probably has alcohol related seizure, but hey... this is the United States)

(a) - EEG is pointless. She is obviously having a seizure.
(b) - MRI is a waste of resources, and takes up too much valuable time, and is even sillier considering she is having seizures.
(d) Sensitivity too low.
(e) And what do we wish to diagnose with an LP?
(e)
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#3
bill - bilallll

A CT scan would be the obvious answer. In academic pursuit, what could be the significance of hyponatremia in this case? Hyponatremia itself can cause seizures, as can a bleed intracranially per se. The explanation to this question from its source contained Intracerebral hemorrhage as the specific diagnosis to the scene. Cerebral Sodium Wasting Disease as a sequale to intacerebral hemorrhage or head injury notwithstanding, couldn't a SAH/Head injury produce hyponatremia via SIADH?
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#4
abrar

Guys....agreed that CT scan is the most obvious answer but just for the sake of discussion....What about LP?
Isn't it very cost effective procedure to r/o SAH?Would be Xanthochromic in this case.
Thanks.
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#5
skynerve

LP cost-effective?! You need a trained doctor, to sit down for 1 hour, use up a few needles etc. etc., get consent from the patient who thinks you're going to perform brain surgery on him, irritate the patient to no end by twisting him in an awkward position, and end up sedating him to keep him quiet, then keep him for 2 days in the ward because of post-LP headache (consultant doesn't want to discharge...) I'd rather wake the radiographer, so I can sleep anyway. Wink A non-contrast CT is risk free, and keeps the patient and the consultants happy.

OK, just kidding, but that's part of the true story.

LP is not going to tell you if there is an extradural hematoma. It's difficult (but subjectively possible) to differentiate SAH from a bloody tap, and no one is going to believe you anyway. Also, xanthochromia doesn't appear till 6-8 hrs, so that's a close to useless finding.

Nobody cares what the sodium is, and why it's 115 at this point as long as she's not seizing on us currently; even whether it's acute SIADH or cerebral salt wasting. Policy - scan first as you replace volume and salt.

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#6
bill - bilallll

Thankz again!

I agree with skynerve as to the answer, but I repeat, only to know what could be the cause of this patient's hyponatremia based on the scenario? The question could take the form of a stem with different options, like what is the probable diagnosis here?
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#7
abrar

Thanks Skynerve,that was informative.
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#8
bill

Anybody on a diagnosis?
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#9
abrar

Bill.....Hyponatraemia could be the result of head injury via SIADH like you mentioned earlier.
Can't think of anything else.
Cerebral salt wasting.....don't know much about that.
Thanks
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#10
skynerve

Well, you can run through the differential causes, but based on the high bicarbonate and low blood pressure - it suggests that the body in an acute situation is losing lots of fluids which are sodium rich. I would have bet on status epilepticus with poor intake of water / salt rather than 'cerebral salt-wasting'. (despite whatever the older literature tells you, CSW is rare)
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