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Clone of cancer cells are resistant to vincristine, doxorubicin, & dactinomycin. But not to methotrexate & alkylating agents. Mech of resistance is?
a. absence of superoxide dismutase
b. Altered DNA polymerase
c. enhanced drug transport out of the cell
d. inability to form polyglutamates
e. increased Dnase
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I found from other forum that the answer to this ques. is C since it is multidrug resistance. Can we try to answer which other anticancers are inactivated by these mechanisms.
A would be doxorubicin, bleomycin since they make free radicals
B alkylating agents
C
D
E
I need help in this one
Please
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Thanks!!!
Can you help me to answer which anticancers use these different mechanisms or I don't have to know that.
Thanks in advance
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D-- methotrexate?? not so sure
need to look up
