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30. A 32-year-old woman has a 10-year history of chronic paranoia, auditory hallucinations, and the belief that characters in television programs are talking directly to her. Drug therapy is most likely to directly involve which of the following neurotransmitter systems?
A ) Acetylcholine
B ) γ-Aminobutyric acid (GABA)
C ) Dopamine
D ) Glutamate
E ) Norepinephrine
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i think it is D(schizophrenic symptom),gl
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GABA-ergic medications may have a potential role in the treatment of schizophrenia. Laboratory evidence has generally supported the ability of G-aminobutyric acid (GABA) to reduce dopaminergic activity and has suggested that GABA may be effective in combating hypofrontality by acting on mesoprefrontocortical tracts in patients resistant to treatment with antipsychotic drugs.
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Guys, in FA 2005 p.121, there is neurotransmitter changes with disease.
Schizophrenia---due to increased dopamine. Answer :c
I will list all the associations here:
Anxiety--increased NE, decreased GABA and 5-HT
Depression--decreased NE, decreased 5-HT
Huntington disease--decreased GABA and Ach
Schizophrenia---due to increased dopamine (DA)
Parkinson's--decreased DA
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Yes, C.
Tx of schizo:
typical antipsychotics: act through DA receptor blockade (mostly D2 and D4 subtypes)
atypical antipsychotics: act through 5-HT2 and DA antagonism.
