Osteoporosis Q - jlx

[ArchivalUser]

A 76-year-okl woman comes to the physician because of severe back pain for the past 2 weeks. She has no history of smoking. She has been taking prednisone (30 mglday) for rheumatoid arthritis for the past 6 months and has received hormone replacement therapy with estrogen and progesterone for the past 15 years. Calcium and vitamin 0 intake are adequate. X-rays of the spine show a vertebral fracture. Which of the following is the most likely cause of the fracture?
o A) Decreased bone formation due to decreased calcium absorption
o B) Decreased bone formation due to inhibition of osteoblast differentiation
o C) Increased bone resorption due to decreased calcium absorption
o D) Increased bone resorption due to decreased serum parathyroid hormone concentration
o E) Increased bone resorption due to estrogen receptor defect

Explanation is appreciated

[ArchivalUser]

E?????

[ArchivalUser]

Corticosteroids have several adverse effects on bone metabolism.

Direct inhibition of osteoblast function
Direct enhancement of bone resorption
Inhibition of gastrointestinal calcium absorption
Increases in urine calcium loss
Inhibition of gonadal hormones

B is most suitable.

[ArchivalUser]

i would go with B

[ArchivalUser]

@carolwang is it copy and paste!!!!!!!!!!!!!!