question - jt885

[ArchivalUser]

Continuous administration of Gonadotropin- releasing hormone is most likely to elicit which of the following long-term changes in the release of LH and FSH

A. Decrease
B. Increase
C. Loss of cyclicity w/o a net increase or decrease
D. No net change in net release or cyclicity

My answer: (A) As it said in first-aid.

For example Leuprolide (agonist properties when use in pulsatile fashion, antagonist properties when used in continuous) fashion

I'm getting contradicting answer with B.

By the way this is from NBME 7 Block 1 Q 11

[ArchivalUser]

agree with "A"

"B' would be the case in the "Initial stage" of GnRH administration.

[ArchivalUser]

Downregulation of receptors due to continued stimulation in long term....B!

[ArchivalUser]

uworld says it is A

[ArchivalUser]

Carol, Where did find that in the uworld ?

[ArchivalUser]

pharmacology, endocrine.
The question stem is about a men ha prostate cancer, then given Leuprolide (GnRH analog) continously. This result in initially increase in FSH and LH and then suppressed in long term. The sex hormone changes in the same fashion.

Text from Wiki
Leuprolide acts as an agonist at pituitary GnRH receptors. By interrupting the normal pulsatile stimulation and the desensitization of the GnRH receptors; it indirectly down regulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) leading to hypogonadism and thus a dramatic reduction in estradiol and testosterone levels in both sexes.