questions - bones

[ArchivalUser]

1.28yr old woman with 39.3 deg temp with substernal chest pain after being treated for gingivitis . x-ray shows enlarged heart. on percardiocentesis 250 ml of cloudy fluid containing large nos of nuetrophils are removed. diag?
1.AFB 2. Budding yeast 3. DNA virus 4. gm neg bacilli
5. Gm + cocci

2.50 yr old man with familial hypercholestremia( AD). His son is not tested for hypercholestraemia. What is the prob the pts grand daughter through his son will have hypercholestraemia
a. <1 b. 10% c. 25% d. 33 % e. 50 %

3. %yr old boy with rec ear infection recieves preschool booster imm against DPT. He is participating in a study to determine humoral response to tt( tet toxoid) His response is below normal for age and sex matched children. peripheral B & T lymphocyte is wnl.The Ab he makes is + in both haemagglutination and complement mediated haemolysis of tt coated erythrocytes. His Ab do not opsonize tt coated latex particle for phagocytosis& do not ppt tt effectively. The child has a defect of
a. affinity maturation of Ig
b. Ig isotype switching
c.Recurrence of heavy chain variable region
d. " " light chain "
e. somatic mutation of Ig

4. C1 esterase inh defeciency- diagnosis
a. decreased C4
b.increased properdin
c normal conc of C1q
d. " " of C1s
e. " " of C2
kindly explain

[ArchivalUser]

1. 5

2. C 25%

3. B He can make only IgM but not IgG due to defect in class switching, So he can activate complement (IgM) but can't opsonize (IgG)

4. Answer is A ..Due to the deficiency of c1 esterase, early components of compliments used up more rapidly. C4 decrease.

[ArchivalUser]

Hi prs
can you explain the 1st and 2nd answers?
thanx

[ArchivalUser]

1. pericarditis after dental work, that suggest strep mutan. That's a G+ cocci, isn't it?

2.Man's disease's onset is late, so he is heterozygous for this autosomal dominant disease, Aa, married a woman aa------Aa, Aa, aa, aa-----so 1/2 is the chance that his son will carry A gene, ---------same calculation once again then his son's daughter will have 1/2 chance to be Aa, so final answer: 1/2x1/2=1/4=25%