p53 1 allele deletion why?? - risenshine

[ArchivalUser]

p53 is a tumor suppressor gene so it would be 2 allele lost to get loss of function and I chose that as as answer= 2 allele deletion, but the answer was not 2 but 1 allele deletion. I still don't understand why.

[ArchivalUser]

It depends on question,
you are right if they ask what should be done for oncogenesis through p53 mutation to occur
you are wrong if they ask about Li Fraumini.

[ArchivalUser]

Yeah, it was about Li Fraumini Mr. Genius. Can you please tell me why would it be wrong in that case?

[ArchivalUser]

P53 is a cornerstone of cellular proliferation, dna repair and apoptosis and few other things I am not aware of. You see, if both alleles were mutated in every cell of the pt since conception, he or she wouldn't, probably, had been born.

[ArchivalUser]

agree with blanc.....P53 has mnay functions, if both absent , child would not have been born.....

[ArchivalUser]

In first aid it says it's a tumor suppressor gene with 2 genes deletion not 1 causing function loss and I chose that for an answer when asked. I still don't get why I was wrong.

[ArchivalUser]

One allele undergoes a germ line mutation
And after birth it's a somatic mutation so maybe it was something in those terms