Acetaminophen toxicity - gogock

[ArchivalUser]

MZB 3 =pg 493 says NAC to any pt with possible overdoes and don't wait till the serum level result comes .

but Uw q #3136 pt with unknown [pt said 14tab] dose comes wait till 4th hour after intoxication to even determine the serum acetaminophen level and immediate NAC not the answer

how do u see it ?

Thx

[ArchivalUser]

According to Harrison's

In a pt with high acetaminophen blood levels (more than 200microgm/ml AT 4 HRS or more than 100microgm/ml AT HRS AFTER INGESTION) administration of NAC reduces the severity of hepatic necrosis.

So, determination of secum acetaminophen level does looks the right choice before starting NAC.

Hope this was helpful. If any further suggestions/inputs please do so. We are all learning here )

[ArchivalUser]

Thx