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NBME 17 - Help Please - Test in 4 days! - tombear
#1
9. A 24-year-old man with a history of intravenous drug use is brought lo the emergency department by his roommate 30 minutes after he could not be aroused. The friend reports that the
patient injected himself with a drug approximately 6 hours ago. Laboratory studies show a serum drug concentration of 0.30 mg/L. Assuming the drug exhibits first-order one-compartment
kinetics, has a half-life of 2 hours, and a volume of distribution of 200 L in this patient, which of the following is the most likely approximate quantity of the drug (in mg) injected?
0 A) 300
0 8) 480
0 C) 600
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#2
0 D) 1000
0 E) 1250
Reply
#3
It's not 600
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#4
B - 480

total concentration = 0.30 mg/L x 200 L = 60 mg

6 hours ago drug was taken....
right now its 60 mg in body
half life 2 hours

go backwards...
6 hours = 60
4 hours = 120
2 hours = 240
0 hours (time of injection) = 480 mg

therefore answer B = 480 mg
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#5
When I took the practice NBME, I found the answers very easily by doing a search online...

Just Google: TestPirates Step 1 NBME 17 answers
they have posted all the questions and answers

Good luck mate!
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