a question from NBME13, is C the right answer? - presteps

[ArchivalUser]

A 22-year-old man comes to the physician because of a 2-year history of episodes of shortness of breath and wheezing. His respirations are 12/min. Physical examination shows no abnormalities. It is found that the symptoms occur after he takes certain over-the-counter medications containing aspirin. Laboratory studies show a serum IgE concentration within the reference range and no eosinophilia. This patients symptoms are most likely caused by excessive production of which of the following substances?
A. Cyclooxygenase
B. Hydroxyeicosatetraenoic acid
C. Leukotriens
D. Prostacyclin(PGI,)
E. Prostaglandis
F Thromboxane A,

[ArchivalUser]

Arachinodic Acid -> release by phospholipase A2 -> Acts upon COX or 5-Lipoxygenase

Where COX -> Prostaglandins (Vasodilation & Increase Vascular Permeability) etc...
Where 5-lipoxygenase -> Leukotriens (Slow reactive substances of anaphylaxis) mediate vasoconstriction, bronchospasm etc...


From Pathoma (Chapter 2 p.11)

C is correct.

[ArchivalUser]

Thank you for your explanation. Very clear!