pharm ,Q - mdkhayat

[ArchivalUser]

A dominant negative mutation is found in PPAR.gamma that decreases the bioavailability of nitric oxide from endothelial cells.which of the following drug produce the similar molecular effect to a dominant negative mutation in PPAR-gamma?

1.finasteride
2. flutamide
3.metoprolol
4.retinoic acid
5.tamoxifen

[ArchivalUser]

3?

[ArchivalUser]

any answer?

[ArchivalUser]

I think 3. metoprolol-->b blocker-->block gs-->block camp-->dec NO.
is tht the ans?

[ArchivalUser]

THE CORRECT ANSWER IS 2.
in explanation it said ,bcz it has an effect like PPAR -gamma ,both of them have effect on trascription factor.
effect of both of them are in nucleus.

cann't understand it .

[ArchivalUser]

I think metoprolol too.
@ khayat, are u planning to give your exam in October by any chance ? If so we can guide each other through if you are willing to.

[ArchivalUser]

yes ,in october .no time ,many things for review.

[ArchivalUser]

5