Antibiotic-associated diarrhea - hsar

[ArchivalUser]

If Metronidazole does not work, do we give Vancomycin IV or Oral????

[ArchivalUser]

C'mon!!! You guys always make me ask twice!!! Allright....I will do it.....

Please....clear this doubt for me!

[ArchivalUser]

ok hsar thx forthe question
first of all u have to discontinue the causative antibiotic and give IV fluids and correct electrolytes ,then if this didn`t work or u can`t discontinue the AB then u add oral metronidazole which is preferable on Vancomycine(ORALLY).
Mertranidazole if didn`t work then u will go to oral vancomycine
look :
metronidazole is preferable because:
less expensive and minimize the emergance of vancomycine resisitant Enterococcus.

I hope it`s clear now::)))))))

[ArchivalUser]

Yes, thank you! So we give oral vancomycin instead of IV because IV vancomycin does not cross the bowel wall but Oral does.

[ArchivalUser]

and to hsaar or anyy body ; what is the side effet of metronidazole and what is the side effect of vancomycin/?

why are U so much worried ABOUT VRE?

[ArchivalUser]

Metronidazole: Common S/E N, V, D, dyspepsia, metallic taste. Disulfiram-like rxn with alcohol, Seizures & Peripheral neuropathy

Vancomycin: Nephrotoxicity, Ototoxicity, Thrombophlebitis & flushing ("red man/red neck syndrome, which can be prevented by pretreatment with antihistamines & slow infusion rate)