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Which abnormality causes an increase risk for infection in a grandma who was previously healthy has half a week of back pain, conjunctival pallor, tenderness over L1 and L2, multiple lytic lesion in the skull and long bones? Lab shows 28% plasma cells via BM aspiration, a monoclonal protein via immunoglobulin electrophoresis, hemoglobin 9.4, leukocyte count 4500, serum BUN 42, serum Cr. 3.6.
1. No effective antibodies
2. Impaired oxidative met. of granulocytes
3. Defective intracellular bact. lysis
4. Def. complement production
5. Def. chemotaxis
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key words leading to your choice
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case of multiple myeloma in which white cells are there but defective.....so i choose that
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totally agree with norwalk - cause for increased infection is due to defective neutrophils..and only option 2 adresses that
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hypogamma globenaemia is the key word you may be looking for.
impaired oxidative metabolism of granulocyte reminds us chronic granulomatos disease.
defective intracellular bacterial lysis may be phagocytic deficiency
defective complement will be angioedema and 5678 deficiency where gonococcal infection and gonorrhea becomes more likely if exposed.
defective chemotaxis is chediak higashi syndrome with oculocutenous alibism neuropathy and neutropenia/? --
so a is the only answer here.
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i agree with djyoti......thanks
