08-09-2017, 03:37 PM
Cause crystalluria with renal tubular obstruction during high-dose, parenteral therapy, specially in inadequate hydrated patients.
Acyclovir is recommended to prevent the outbreaks and Tx in Herpes Genitalis. Acyclovir inhibits viral DNA synthesis.
It is use in the Tx of HERPES ENCEPHALITIS (Leading cause of Sporadic Necrotizing Encephalitis)
In this cases Acyclovir acts doing the following reaction:
Acyclovir is an acyclic analogue of the natural nucleoside Guanosine.
Acyclovir is efficiently phosphorlyated at a rapid rate by virus-specific THYMIDINE KINASE (TdK), but is slowly phosphorylated by the host TdK
The affinity of acyclovir for TdK produce by normal host cells is approx 250 times less than for the TdK induced by Herpes Simplex Virus
This selective affinity results in the activation and concentration of Acyclovir in virus-infected cells.
Once Acyclovir is converted into acyclovir monophosphate by the viral TdK, it is further converted to acyclovir thriphosphate by other cellular enzymes
Acyclovir triphosphate competes w/ deoxyguanosine thriphosphate for binding to the HSV DNA polymerase.
When it is incorporated into the viral DNA, it prevents further elongation of the chain.
Acyclovir is recommended to prevent the outbreaks and Tx in Herpes Genitalis. Acyclovir inhibits viral DNA synthesis.
It is use in the Tx of HERPES ENCEPHALITIS (Leading cause of Sporadic Necrotizing Encephalitis)
In this cases Acyclovir acts doing the following reaction:
Acyclovir is an acyclic analogue of the natural nucleoside Guanosine.
Acyclovir is efficiently phosphorlyated at a rapid rate by virus-specific THYMIDINE KINASE (TdK), but is slowly phosphorylated by the host TdK
The affinity of acyclovir for TdK produce by normal host cells is approx 250 times less than for the TdK induced by Herpes Simplex Virus
This selective affinity results in the activation and concentration of Acyclovir in virus-infected cells.
Once Acyclovir is converted into acyclovir monophosphate by the viral TdK, it is further converted to acyclovir thriphosphate by other cellular enzymes
Acyclovir triphosphate competes w/ deoxyguanosine thriphosphate for binding to the HSV DNA polymerase.
When it is incorporated into the viral DNA, it prevents further elongation of the chain.