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pharm related Q - nickmle
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06-22-2006, 03:58 PM
The principal drug recommended for treatment of this patient's disease(TB) targets which of the following molecules?
A. Arabinogalactan B. Dihydrofolate reductase C. Dihydropteroate synthetase D. Mycolic acid E. Peptidoglycan
06-22-2006, 04:09 PM
yes guys its D....
EXPL for the others...take a look The correct answer is D. The mainstay of therapy for tuberculosis is treatment with drugs such as isoniazid, rifampin, ethambutol, ethionamide, pyrazinamide, and streptomycin. Both isoniazid and ethionamide target the mycolic acid molecules in the mycobacterial cell wall. A single drug, usually isoniazid, can be used for chemoprophylaxis and when clinical disease is absent. Multiple drugs are usually used in other settings. Mycobacterium tuberculosis resistant to all first-line drugs is being seen with increasing frequency among AIDS patients. Arabinogalactan (choice A) is the molecule targeted by ethambutol, which is a drug added to the anti-mycobacterial regimen only when drug-resistant strains are implicated. Dihydrofolate reductase (choice B) is the molecule targeted by trimethoprim, which is not the principal drug recommended for treatment of tuberculosis. Dihydropteroate synthetase (choice C) is the molecule targeted by dapsone, which is the drug of choice for Mycobacterium leprae, not M. tuberculosis. Peptidoglycan (choice E) is the molecule targeted by the penicillins, vancomycin, and cycloserine.
06-22-2006, 04:11 PM
thanks nickmle... now its registered in the brain forever!!!!
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