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+--- Thread: pharm Q - boggart (/showthread.php?tid=141206)
pharm Q - boggart - ArchivalUser - 11-25-2006
A 24yo woman who takes antihistamine (terfenadine) for recurrent urticaria collapses suddenly in the hospital concourse. The resuscitation team notes polymorphic VT (torsade de pointes). A drug-induced arrhythmia is suspected.
Which of the following is most likely to have caused the interaction with the terfenadine?
A- combined OCP
B- grapefruit juice
C-ibuprofen
D-acetoaminophen
E-st john's wort
0 - ArchivalUser - 11-25-2006
b or e??b
0 - ArchivalUser - 11-28-2006
tough one
0 - ArchivalUser - 11-28-2006
B- grapefruit juice??
is grapefruit juice P450 inducer or inhibitor?
0 - ArchivalUser - 11-28-2006
B- grapefruit juice----inhibit cythcrome p450 --inc level terfenadine---torsad