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pharm Q - boggart

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pharm Q - boggart
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#1
11-25-2006, 02:01 AM
A 24yo woman who takes antihistamine (terfenadine) for recurrent urticaria collapses suddenly in the hospital concourse. The resuscitation team notes polymorphic VT (torsade de pointes). A drug-induced arrhythmia is suspected.

Which of the following is most likely to have caused the interaction with the terfenadine?

A- combined OCP
B- grapefruit juice
C-ibuprofen
D-acetoaminophen
E-st john's wort
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#2
11-25-2006, 02:06 AM
b or e??b
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#3
11-28-2006, 01:39 PM
tough one
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#4
11-28-2006, 02:26 PM
B- grapefruit juice??
is grapefruit juice P450 inducer or inhibitor?
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#5
11-28-2006, 02:38 PM
B- grapefruit juice----inhibit cythcrome p450 --inc level terfenadine---torsad
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