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+--- Thread: amytriptyline - kashmala (/showthread.php?tid=164050)
amytriptyline - kashmala - ArchivalUser - 02-22-2007
cause of death in pt with amytryptilline overdose?
1.serotonin uptake
2.norepinefrine accumulation
3.uncontrolled presynaptic dopamine realease
4.Na channel bloeckage
5.CL channel overactivity
0 - ArchivalUser - 02-22-2007
i guess..bbbbbbbb NE uptake block.......
0 - ArchivalUser - 02-22-2007
2.norepinefrine accumulation
0 - ArchivalUser - 02-22-2007
b?
0 - ArchivalUser - 02-22-2007
2..norepinefrine accumulation
0 - ArchivalUser - 02-22-2007
not sure..but....main effect of TCA overdose is hypotension and cardiotoxicity....NE and serotonin initially accumulates....so the initial excitatory effects..than they are depleted ...so produces hypotension....it should be either 3..4..or..5...may be 333333..i m not sure though
0 - ArchivalUser - 02-22-2007
44...
0 - ArchivalUser - 02-22-2007
44...
0 - ArchivalUser - 02-22-2007
weldone pongly....doing great
0 - ArchivalUser - 02-22-2007
amytriptilline inhibits
presynaptic neurotransmitter uptake(serotonin n NE) casuing tremors n insomnia
it inhibits FAST Na CNAHHEL causing conduction defects,hypotension n arrythmias
it aslo inhibits muscarinic receptors(acetylcholine) causing hyperthermia,flushing,dilated pupil,Intestinal ileus,urinary retention n constipation
it inhibits alfa adrenergic receptors casuing peripheral vasodilatation( orthostatic hypotention)
it inhibits histamine receptor (H1) causing sedation