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amytriptyline - kashmala
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02-22-2007, 09:56 AM
cause of death in pt with amytryptilline overdose?
1.serotonin uptake 2.norepinefrine accumulation 3.uncontrolled presynaptic dopamine realease 4.Na channel bloeckage 5.CL channel overactivity
02-22-2007, 10:15 AM
not sure..but....main effect of TCA overdose is hypotension and cardiotoxicity....NE and serotonin initially accumulates....so the initial excitatory effects..than they are depleted ...so produces hypotension....it should be either 3..4..or..5...may be 333333..i m not sure though
02-22-2007, 10:27 AM
amytriptilline inhibits
presynaptic neurotransmitter uptake(serotonin n NE) casuing tremors n insomnia it inhibits FAST Na CNAHHEL causing conduction defects,hypotension n arrythmias it aslo inhibits muscarinic receptors(acetylcholine) causing hyperthermia,flushing,dilated pupil,Intestinal ileus,urinary retention n constipation it inhibits alfa adrenergic receptors casuing peripheral vasodilatation( orthostatic hypotention) it inhibits histamine receptor (H1) causing sedation |
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