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Digitalis toxicity - doc_vic - Printable Version +- USMLE Forum - Largest USMLE Community (https://www.usmleforum.com) +-- Forum: USMLE Forum (https://www.usmleforum.com/forumdisplay.php?fid=1) +--- Forum: Step 1 (https://www.usmleforum.com/forumdisplay.php?fid=2) +--- Thread: Digitalis toxicity - doc_vic (/showthread.php?tid=391286) Pages:
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Digitalis toxicity - doc_vic - ArchivalUser - 03-10-2009 anyone knows MOA for thiazide increasing digitalis toxicity? same as lithium by increasing reabsorption in PCT? 0 - ArchivalUser - 03-10-2009 electrolyte imbalance 0 - ArchivalUser - 03-10-2009 hypokalemia caused by thiazides causes digitalis toxicity 0 - ArchivalUser - 03-10-2009 hi vikisin. how hypokalemia enhance digitalis activity? anybody pls explain? 0 - ArchivalUser - 03-10-2009 both hyper and hypokalemia can cause arrhythmia. I dont know how but this is my guess. In hypokalemia extracellular k is low so more potassium would rush out or less would go out leading to defect in phase 3 and 4 and can lead to defective or less repolarization and premature beats or delayed after depolarizations. wild 2 min guess. 0 - ArchivalUser - 03-10-2009 both hyper and hypokalemia can cause arrhythmia. I dont know how but this is my guess. In hypokalemia extracellular k is low so more potassium would rush out or less would go out leading to defect in phase 3 and 4 and can lead to defective or less repolarization and premature beats or delayed after depolarizations. wild 2 min guess. 0 - ArchivalUser - 03-10-2009 both hyper and hypokalemia can cause arrhythmia. I dont know how but this is my guess. In hypokalemia extracellular k is low so more potassium would rush out or less would go out leading to defect in phase 3 and 4 and can lead to defective or less repolarization and premature beats or delayed after depolarizations. wild 2 min guess. 0 - ArchivalUser - 03-10-2009 both hyper and hypokalemia can cause arrhythmia. I dont know how but this is my guess. In hypokalemia extracellular k is low so more potassium would rush out or less would go out leading to defect in phase 3 and 4 and can lead to defective or less repolarization and premature beats or delayed after depolarizations. wild 2 min guess. 0 - ArchivalUser - 03-10-2009 SORRY...I HAVE NO IDEA WHY IT POSTED IT SO MANY TIMES SORRY 0 - ArchivalUser - 03-10-2009 I am just copy/pasting. According to Katzung, 'INTERACTIONS WITH POTASSIUM, CALCIUM, AND MAGNESIUM Potassium and digitalis interact in two ways. First, they inhibit each other's binding to Na+/K+ ATPase; therefore, hyperkalemia reduces the enzyme-inhibiting actions of cardiac glycosides, whereas hypokalemia facilitates these actions. Second, abnormal cardiac automaticity is inhibited by hyperkalemia (see Chapter 14). Moderately increased extracellular K+ therefore reduces the effects of digitalis, especially the toxic effects.' |