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+--- Thread: Digitalis toxicity - doc_vic (/showthread.php?tid=391286)
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Digitalis toxicity - doc_vic - ArchivalUser - 03-10-2009
anyone knows MOA for thiazide increasing digitalis toxicity? same as lithium by increasing reabsorption in PCT?
0 - ArchivalUser - 03-10-2009
electrolyte imbalance
0 - ArchivalUser - 03-10-2009
hypokalemia caused by thiazides causes digitalis toxicity
0 - ArchivalUser - 03-10-2009
hi vikisin.
how hypokalemia enhance digitalis activity?
anybody pls explain?
0 - ArchivalUser - 03-10-2009
both hyper and hypokalemia can cause arrhythmia.
I dont know how but this is my guess. In hypokalemia extracellular k is low so more potassium would rush out or less would go out leading to defect in phase 3 and 4 and can lead to defective or less repolarization and premature beats or delayed after depolarizations.
wild 2 min guess.
0 - ArchivalUser - 03-10-2009
both hyper and hypokalemia can cause arrhythmia.
I dont know how but this is my guess. In hypokalemia extracellular k is low so more potassium would rush out or less would go out leading to defect in phase 3 and 4 and can lead to defective or less repolarization and premature beats or delayed after depolarizations.
wild 2 min guess.
0 - ArchivalUser - 03-10-2009
both hyper and hypokalemia can cause arrhythmia.
I dont know how but this is my guess. In hypokalemia extracellular k is low so more potassium would rush out or less would go out leading to defect in phase 3 and 4 and can lead to defective or less repolarization and premature beats or delayed after depolarizations.
wild 2 min guess.
0 - ArchivalUser - 03-10-2009
both hyper and hypokalemia can cause arrhythmia.
I dont know how but this is my guess. In hypokalemia extracellular k is low so more potassium would rush out or less would go out leading to defect in phase 3 and 4 and can lead to defective or less repolarization and premature beats or delayed after depolarizations.
wild 2 min guess.
0 - ArchivalUser - 03-10-2009
SORRY...I HAVE NO IDEA WHY IT POSTED IT SO MANY TIMES SORRY
0 - ArchivalUser - 03-10-2009
I am just copy/pasting.
According to Katzung,
'INTERACTIONS WITH POTASSIUM, CALCIUM, AND MAGNESIUM
Potassium and digitalis interact in two ways. First, they inhibit each other's binding to Na+/K+ ATPase; therefore, hyperkalemia reduces the enzyme-inhibiting actions of cardiac glycosides, whereas hypokalemia facilitates these actions. Second, abnormal cardiac automaticity is inhibited by hyperkalemia (see Chapter 14). Moderately increased extracellular K+ therefore reduces the effects of digitalis, especially the toxic effects.'