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+--- Thread: path q - timbucktoo (/showthread.php?tid=525268)
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path q - timbucktoo - ArchivalUser - 08-13-2010
molecular studies on a abdominal lymph node containing lymphoma demonstrate t(2;8)(p12;q24) translocation. This is most compatible with which of the following dzs?
a. mantle cell lymphoma
b. burkitt's lymphoma
c. multiple meyeloma
d. small cell lymphoma
e. small cleved cell lymphoma
0 - ArchivalUser - 08-13-2010
BBBBBBB
0 - ArchivalUser - 08-13-2010
bbb
0 - ArchivalUser - 08-13-2010
burkitt's lymphoma is 8:14 translocation..
please explaine why this lymphoma demonstrate t(2;8)(p12;q24) translocation
0 - ArchivalUser - 08-13-2010
lymphoma demonstrate t(2;8)(p12;q24) translocation?
but burkitt's lymphoma is 8:14 translocation...please explaine ur answers
0 - ArchivalUser - 08-13-2010
I had to look it up, t(2,8) is a variant of Burkitt cell lymphoma so it seems. Although I don't recall seeing this in the notes. Probably useful to keep it in mind. Since I hear these days Step 1 has gotten kinda whack and throwing questions from left field
0 - ArchivalUser - 08-13-2010
i did found this:
Burkitt's lymphoma is associated with a chromosomal translocation of the c-myc gene. This gene is found at 8q24.
The most common variant is t(8;14)(q24;q32).
A variant of this, a three-way translocation, t(8;14;18), has also been identified.
A rare variant is at t(2;8)(p12;q24).
Another rare variant is t(8;22)(q24;q11).
NOT mentioned in kaplan LNs,nor FA 2009
0 - ArchivalUser - 08-13-2010
its seems that q24 defect is present in all 3 types!!good way to recall
0 - ArchivalUser - 08-13-2010
yeah goforusmle, I agree with you. Although Kaplan and FA do their best to cover most material. They cover the HIGH YEILD stuff. Just because something is not mentioned doesn't mean it wont be tested. Perhaps it is questions like that, that distinguish the average student from the top student.
Hooray!
0 - ArchivalUser - 08-13-2010
bbbb....is the correct answer...and explained well above....