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path q - timbucktoo
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08-13-2010, 08:34 AM
molecular studies on a abdominal lymph node containing lymphoma demonstrate t(2;8)(p12;q24) translocation. This is most compatible with which of the following dzs?
a. mantle cell lymphoma b. burkitt's lymphoma c. multiple meyeloma d. small cell lymphoma e. small cleved cell lymphoma
08-13-2010, 01:51 PM
burkitt's lymphoma is 8:14 translocation..
please explaine why this lymphoma demonstrate t(2;8)(p12;q24) translocation
08-13-2010, 01:53 PM
lymphoma demonstrate t(2;8)(p12;q24) translocation?
but burkitt's lymphoma is 8:14 translocation...please explaine ur answers
08-13-2010, 02:09 PM
I had to look it up, t(2,8) is a variant of Burkitt cell lymphoma so it seems. Although I don't recall seeing this in the notes. Probably useful to keep it in mind. Since I hear these days Step 1 has gotten kinda whack and throwing questions from left field
08-13-2010, 02:27 PM
i did found this:
Burkitt's lymphoma is associated with a chromosomal translocation of the c-myc gene. This gene is found at 8q24. The most common variant is t(8;14)(q24;q32). A variant of this, a three-way translocation, t(8;14;18), has also been identified. A rare variant is at t(2;8)(p12;q24). Another rare variant is t(8;22)(q24;q11). NOT mentioned in kaplan LNs,nor FA 2009
08-13-2010, 02:30 PM
its seems that q24 defect is present in all 3 types!!good way to recall
08-13-2010, 02:42 PM
yeah goforusmle, I agree with you. Although Kaplan and FA do their best to cover most material. They cover the HIGH YEILD stuff. Just because something is not mentioned doesn't mean it wont be tested. Perhaps it is questions like that, that distinguish the average student from the top student.
Hooray!
08-13-2010, 04:45 PM
bbbb....is the correct answer...and explained well above....
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