regarding the ati cancer drugs. - jesh

[ArchivalUser]

can any one please give me the list of drugs which are cell cycle specific

[ArchivalUser]

I don't have the complete list: but some include vincristine, 5-Floro uracil, etopoxide, taxels (doxitaxel), hydroxyurea.....

[ArchivalUser]

thanks, but i would like to knew,that all these drugs are acting in which phases of cell cycle.

[ArchivalUser]

Jesh, here are the specific phases in w/c they act:
Antimetabolites (e.g. 5 Flourouracil)...............................S
Alkaloids (e.g. Doxorubucin, ActinomycinD)....................S and M
Vincristine...................................................................M
Topo inhibitors (e.g. Etopoxide).....................................S
Taxanes (e.g. Docetaxel)..............................................M
Hydroxyurea ..............................................................?S (not well known)
Az

[ArchivalUser]

thanks for ur response.

[ArchivalUser]

bleomycin acts in G2 phase

[ArchivalUser]

etoposide acts on both G2 and S phase.
correct me if i am wrong.

[ArchivalUser]

Ya, makes sense.
In G2,cells are transcriptionaly active and need the Topo II to deal with changing topology during the process.
But I think cells need it more during S phase, that may be why thy put it under S-specific.