Anti cancer drugs acting in S phase - raji_321

[ArchivalUser]

methotrexate- inhibits dihydrofolate reductase

mercaptopurine and thioguanine (both purine analogues that inhibit purine synthesis),
azacytidine (limits pyrimidine synthesis by inhibiting orotidylate decarboxylase),

hydroxyurea (inhibits formation of deoxyribonucleotides from ribonucleotides),

5-fluorouracil (inhibits thymidylate synthase) and

cytarabine (AKA cytosine arabinoside, which inhibits DNA
polymerase).

any more??

[ArchivalUser]

daunorubicin and doxorubicin.

[ArchivalUser]

hi joannitam, both daunorubicin and doxorubicin are not mentioned in kaplan pharma under S phase..
so i browsed... it seems that these are cell cycle nonspecific drugs. explanation.. those that bind directly to DNA are not cell cycle specific

Duanorubicin & doxo (binds to and intercalates DNA, DNA strand breakage and inhibition of the enzyme topoisomerase II)

[ArchivalUser]

other examples of cell cycle nonspecific drugs-- dactinomycin, mithramycin

[ArchivalUser]

Etoposide is also S phase drug. ( eukaryotic topoismomerase inhibitor)