05-22-2008, 10:00 AM
Doxorubicin (Adriamycin), daunorubicin
Mechanism Generate free radicals and noncovalently intercalate in DNA (creating breaks in DNA
strand to ↓ replication).
Clinical use Part of the ABVD combination regimen for Hodgkin™s and for myelomas, sarcomas, and
solid tumors (breast, ovary, lung).
Toxicity Cardiotoxicity; also myelosuppression and marked alopecia. Toxic extravasation
Mechanism Generate free radicals and noncovalently intercalate in DNA (creating breaks in DNA
strand to ↓ replication).
Clinical use Part of the ABVD combination regimen for Hodgkin™s and for myelomas, sarcomas, and
solid tumors (breast, ovary, lung).
Toxicity Cardiotoxicity; also myelosuppression and marked alopecia. Toxic extravasation