good morning !! self motivational thread - usmle19s

[ArchivalUser]

gp2B3a inhibitors------ all have a "B"


aBciximab (ReoPro)
eptifiBatide (Integrilin)
tirofiBan (Aggrastat)

[ArchivalUser]

what is the most common cause of thrombocytopenia in adults and children ?
what is the treatment ? a. ------ b. ------ c.---------

[ArchivalUser]

microangiopathic hemolytic anemia - schistocytes / helmet cells

two types - TTP/HUS
TTP- decrease in enzyme ( genetic or autoab ) ADAMS ST13
which results in excess vWF multimers ,-abnormal platelet adhesion-> leads to formation of platelet thrombi ( thrombotic)- thrombocytopenia - purpura (TTP)

[ArchivalUser]

isnt glanzman due to Gp2b3a?
MCC of thrombocytopenia is a/c and c/c ITP dont rembr the treatment! think steroids,spenectomy etc

[ArchivalUser]

HUS - CHILDREN / ecoli O157:H7 / verotoxin / endothelial damgae mainly in kidneys - uremia /

TTP- adult femails
ITP- acute - childrem , chronic in adult females of child bearing age group

[ArchivalUser]

sorry my bad - galnzman is due to defect in gp2b3a ,


Rx of ITP - 1. steroids 2. IVIG 3. splenectomy

thanks

[ArchivalUser]

Bernard–Soulier syndrome (BSS), also called hemorrhagiparous thrombocytic dystrophy,[1] is a rare autosomal recessive coagulopathy (bleeding disorder) that causes a deficiency of glycoprotein Ib (GpIb), the receptor for von Willebrand factor, which is important in clot formation.


It is a Giant Platelet Syndrome that is characterized by abnormally large platelets.

[ArchivalUser]

QUALITATIVE PLATELET DISORDERS LIST-

1. bernard soulier
2. glanzman
3. asprin
4. uremia

QUANTITATIVE PLATELET DEFECTS -

1. ITP
2. TTP
3. HUS

[ArchivalUser]

sign out for 3 hrs... will come back with an update of progess :-)

[ArchivalUser]

I remember Glanzmann thrombasthenia as having two N in Glanzmann, so it has GpIIb(two)/IIIa deficiency and Bernard soulier as GpIb deficiency.

Hope it helps to remember the two